This sounds like it’s not the PBC itch. But it may have made it worse. Don’t let them put you off keep seeing docs. If Prednisone isn’t working get off of it! Prednisone is very hard on the Liver in my opinion.
This may be some other Auto immune issue. You might considered seeing a Rheumatologist. Just a thought.
Keep us in the loop.

Hope it gets better!

I take 300 mg twice a day. Probably not enough because I just got DX with Stage 4 on my liver biopsy. And my blood tests are showing an infection some where. So got a bone marrow test Got zillion tests done and Gallbladder removal surgery because of polyps which can turn cancerous. I can't believe all these things going to crap at once. BTW I read the Itching is from (or can come from) high bilirubin. Is yours normal or high? Check out symptoms of high bilirubin if you have it. If so search how to bring it down or help with the itching from the bilirubin.

What is the dosage of Urso that you take? That might have to be bumped up until the itching goes away. I had to do that for a bit. Sorry about the rash, that I have never had.

Thank you Marcy!