Switching from Ocaliva (Obeticholic Acid) to Seladelpar (Livdelzi) is a significant change in your treatment for primary biliary cholangitis (PBC). Here are some key points about both medications:

Ocaliva (Obeticholic Acid)
- Usage: Prescribed for adults who have not responded well to ursodeoxycholic acid (UDCA) or cannot Show Full Answer

Switching from Ocaliva (Obeticholic Acid) to Seladelpar (Livdelzi) is a significant change in your treatment for primary biliary cholangitis (PBC). Here are some key points about both medications:

Ocaliva (Obeticholic Acid)
- Usage: Prescribed for adults who have not responded well to ursodeoxycholic acid (UDCA) or cannot tolerate it.
- Mechanism: Decreases bile production and increases bile removal from the liver.
- Side Effects: Itching, tiredness, stomach pain, rash, joint pain, mouth and throat pain, dizziness, constipation, swelling in hands or feet, fast or irregular heartbeat, fever, changes in thyroid function, and eczema. Rare but serious side effects include liver deterioration, potentially leading to liver failure, transplants, or death.

Seladelpar (Livdelzi)
- Usage: Approved for treating PBC in adults, either in combination with UDCA for those who do not respond adequately to UDCA alone or as a monotherapy for those who cannot tolerate UDCA.
- Mechanism: Reduces alkaline phosphatase (ALP) levels, which are often elevated in PBC.
- Side Effects: Headache, abdominal pain, nausea, abdominal distension (bloating), and dizziness. Rare but serious side effects include fractures, liver test abnormalities, and biliary obstruction.

Considerations
- Effectiveness: Your GI may have recommended the switch based on the latest FDA guidance or clinical evidence suggesting that Seladelpar might be more effective for your specific condition.
- Monitoring: Both medications require careful monitoring by your healthcare provider to manage side effects and ensure effectiveness.

For more detailed information, you can visit the respective pages for [Ocaliva](https://www.myPBCteam.com/treatments/ocaliva) and [Livdelzi](https://www.myPBCteam.com/treatments/livdelzi). Always consult your healthcare provider for personalized advice.

 This AI-generated response comes from myPBCteam and other selected sources. It is not a substitute for medical advice. Always ask your doctor about specific health concerns.

Ocaliva (Obeticholic Acid) for PBC | myPBCteam

Livdelzi (Seladelpar) for PBC | myPBCteam