Modafinil (Provigil) for PBC

Overview
Modafinil is a prescription drug sometimes used to treat fatigue associated with primary biliary cholangitis (PBC). Fatigue is a common symptom of PBC, affecting more than half of people with this chronic liver disease. Modafinil is also known by its brand name, Provigil.

The U.S. Food and Drug Administration (FDA) has approved modafinil for treating excessive sleepiness caused by narcolepsy, obstructive sleep apnea/hypopnea syndrome, or shift work sleep disorder.

Modafinil belongs to a class of drugs called stimulants. Modafinil is believed to work by changing the balance of the neurotransmitters in the brain that control sleep and wakefulness.

How do I take it?
Modafinil comes in tablets that are taken once daily. Individual dosages vary. Be sure to take modafinil exactly as prescribed by your doctor.

Side effects
The FDA-approved label for modafinil lists common side effects including headache, nausea, nervousness, runny nose and stuffiness, diarrhea, back pain, insomnia, dizziness, and indigestion.

Rare but serious side effects listed for modafinil include serious rash such as Stevens-Johnson syndrome, allergic reactions, persistent sleepiness, psychiatric symptoms, and cardiovascular disease.

For more details about this treatment, visit:

Modafinil — MedlinePlus
https://medlineplus.gov/druginfo/meds/a602016.html

Provigil — RxList
https://www.rxlist.com/provigil-drug.htm