Fenofibrate for PBC

Overview
Fenofibrate is a medication which is sometimes prescribed off-label to treat primary biliary cholangitis (PBC) in people who are also taking ursodiol (UDCA). The U.S. Food and Drug Administration (FDA) has approved several brand-name formulations of the drug, including Antara, Fenoglide, TriCor, Triglide, and Trilipix.

Fenofibrate is a member of a class of drugs called fibrates. It works by speeding up the body’s natural processes of removing cholesterol. Scientists have not determined how the drug works to treat PBC, although it seems to reduce inflammation in the liver and itching symptoms for some people, when taken in combination with ursodiol.

How do I take it?
Depending on the formulation, fenofibrate comes in the form of a capsule, a delayed-release capsule, and a tablet, all of which are taken orally. The drug is usually taken once per day. Individual doses vary. Additionally, some formulations should be taken with food whereas others may be taken with or without food.

Side effects
The most common side effects include runny or stuffy nose, sneezing, and abnormal lab tests.

Rare but serious side effects include elevated liver enzymes, increased levels of creatine phosphokinase (CPK), development of gallstones, irregular heartbeat, blockage of the pulmonary arteries, pancreatitis, agranulocytosis, and heart attack.

For more details about this treatment, visit:

Fenofibrate — MedlinePlus
https://medlineplus.gov/druginfo/meds/a601052.html

Fenofibrate — StatPearls
https://www.ncbi.nlm.nih.gov/books/NBK559219/

Fenofibrate — Drugs.com
https://www.drugs.com/fenofibrate.html